The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.
Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects
In this episode, I explain how medications such as Adderall, Ritalin, Vyvanse and other stimulants work to increase focus and treat attention-deficit/hyperactivity disorder (ADHD). I explain the brain circuits involved in focus and the key roles dopamine and norepinephrine play in their regulation. Then I explain how stimulants such as Adderall and Vyvanse can increase focus and reduce hyperactivity in kids or adults with ADHD, and how and why Ritalin and other medications (e.g., Modafinil, Guanfacine) may work better for some. I explain the long-term effects of ADHD medications on height, cardiovascular health, hormones, predisposition to addiction and psychosis, and whether these treatments can be used and then stopped. I also discuss the immense individual variation in dosage sensitivity for these medications and the negative side-effects that occur from recreational use. This episode ought to benefit anyone with ADHD, their parents, those on ADHD medications or anyone curious about how these medications work.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
Maui Nui Venison: https://mauinuivenison.com/huberman
ROKA: https://roka.com/huberman
HVMN: https://hvmn.com/huberman
InsideTracker: https://insidetracker.com/huberman
Momentous: https://www.livemomentous.com/huberman
The Brain Body Contract
Timestamps
(00:00:00) Stimulants & Attention-Deficient/Hyperactivity Disorder (ADHD)
(00:03:21) Sponsors: Maui Nui, ROKA, HVMN
(00:06:35) The Brain-Body Contract
(00:07:22) Attention, Prefrontal Cortex & ADHD
(00:16:27) Stimulants “Sympathomimetics”
(00:21:29) Adderall, Dopamine & Norepinephrine
(00:25:58) Sympathomimetics, Dopamine & Norepinephrine
(00:31:05) Sponsor: AG1
(00:32:20) Vyvanse is Timed-Release D-Amp
(00:36:36) Ritalin, Concerta
(00:40:10) Dopamine & “Noise Reduction”; Norepinephrine & “Signal Amplification”
(00:45:28) ADHD: Focus, Hyperactivity & Impulsivity; Drug Selection & Dose
(00:50:57) How do Stimulants ‘Calm’ ADHD?
(00:54:480 Neuroplasticity & Neuromodulators
(00:58:06) Kids, ADHD Diagnosis & Treatment; Predispose Addiction?
(01:04:02) Sponsor: InsideTracker
(01:05:12) ADHD Medications: Individuality, Doses, Tapering & Long-Term Use
(01:13:28) Medication & Long-Term Effects: Height, Cardiovascular Risk, Alcohol
(01:19:32) Cortisol & Hormones
(01:27:45) Psychosis & Addiction; Methamphetamine
(01:38:20) Recreational Use, Addiction & Psychosis; Habituation
(01:42:30) Drug Holidays; Ritalin & Long-Term Effects
(01:45:35) Modafinil, Armodafinil; Side-Effects
(01:53:03) Guanfacine, Alcohol
(01:58:03) ADHD Medications
(02:00:26) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac