The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.
Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer
In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast.
We each present a peer-reviewed scientific paper chosen because it contains novel, interesting, and actionable data. First, we discuss a paper on how bright light exposure at sunrise and throughout the day and dark exposure at night independently improve mental health and can offset some of the major symptoms of mental health disorders such as depression and anxiety. Then, we discuss an article that explores a novel class of immunotherapy treatments to combat cancer. We also discuss some of the new data on low-calorie sweeteners and if they are safe. This episode should be of interest to listeners curious about maximizing their vitality and longevity and to anyone seeking science-supported ways to improve mental health and lifespan.
For show notes, including referenced articles and additional resources, please visit hubermanlab.com.
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Timestamps
(00:00:00) Dr. Peter Attia, Journal Club
(00:02:40) Sponsors: Eight Sleep, BetterHelp & Joovv
(00:07:14) Light, Dark & Mental Health; Retina
(00:11:16) Outdoor vs. Indoor Light, Cataracts, Sunglasses
(00:16:17) Tools: Sunrise & Sunsets, Circadian Rhythm; Midday Light
(00:24:55) Tools: Night & Light Exposure; Waking Before Sunrise
(00:31:05) Article #1, Light/Dark Exposure & Mental Health
(00:36:50) Sponsor: AG1
(00:38:18) Odds Ratio, Hazard Ratio
(00:45:43) Night vs. Daylight Exposure, Mental Health Disorders
(00:51:35) Major Depression & Light Exposure; Error Bars & Significance
(00:59:15) Sponsor: LMNT
(01:00:39) Prescriptions; Environmental & Artificial Light; Red Lights
(01:08:14) Nighttime Light Exposure; Sleep Trackers & Belief Effects
(01:13:54) Light Directionality, Phone, Night
(01:17:21) Light Wavelengths & Sensors; Sunglasses
(01:20:58) Hawthorne Effect, Reverse Causality, Genetics
(01:26:26) Artificial Sweeteners, Appetite
(01:31:16) Natural Light Cycles, Circadian Rhythm & Mental Health
(01:39:53) Article #2, Immune System & Cancer
(01:43:18) T-Cell Activation; Viruses
(01:50:41) Autoimmunity; Cancer & Immune System Evasion
(02:00:09) Checkpoint Inhibitors, CTLA-4
(02:06:45) Anti-CTLA-4 Study Drug (Ipilimumab), Melanoma
(02:12:07) Patient Population, Randomization, GP100
(02:18:09) Response Rate
(02:22:52) Overall Survival & Response
(02:28:38) Median Survival vs. Overall Survival, Drug Development
(02:35:45) Gender & Dose
(02:40:32) Adverse Events; Autoimmunity
(02:46:42) Pancreatic Cancer; Aging & Immune System Health
(02:53:57) Melanoma; Lynch Syndrome, Keytruda
(02:58:43) Immunotherapy & Cancer Treatment; Melanoma Risk
(03:06:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter