The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health
In this episode, my guest is Dr. Mark D'Esposito, M.D., a neurologist and professor of neuroscience and psychology at the University of California, Berkeley. We discuss the brain mechanisms underlying cognition and the forms of memory required for focus, productivity, planning and achieving goals, and learning. We discuss the neurochemicals such as dopamine and acetylcholine and how they can be leveraged to improve cognitive functioning. We also discuss concussion, traumatic brain injury (TBI), Alzheimer's, and Parkinson's disease, and ways to restore or slow cognitive decline by using pharmacologic, lifestyle and behavioral protocols. This episode provides a modern understanding of cognition and memory and actionable tools to optimize brain health and function.
For show notes, including referenced articles and additional resources, please visit hubermanlab.com.
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Timestamps
(00:00:00) Dr. Mark D’Esposito
(00:02:08) Sponsors: Maui Nui, Joovv & Eight Sleep
(00:06:23) Brain & Frontal Lobes, Prefrontal Cortex, Executive Function
(00:10:31) Frontal Lobe Development, Children
(00:14:12) Rules, Context & Impulse Control; Learning & Goals
(00:21:45) Focus, Improving Executive Function
(00:26:04) Connections & Top-Down Signals
(00:29:02) Sponsor: AG1
(00:30:29) Frontal Lobe Injury; Emotional Regulation
(00:37:26) Smartphones, Social Media
(00:44:37) Working Memory, Dopamine
(00:52:59) Sponsor: LMNT
(00:54:22) Dopamine Levels & Working Memory, Cognitive Tasks, Genetics
(01:00:03) Bromocriptine & Working Memory, Dopamine
(01:06:21) Guanfacine, Neurotransmitter Levels, Pupil Dilation & Biomarker Tests
(01:12:46) Bromocriptine, Olympics; Pharmacology & Cognitive Function, Adderall
(01:19:27) Concussion, Traumatic Brain Injury (TBI)
(01:25:22) Sleep, TBI, Concussion & Executive Function; BrainHQ
(01:31:57) Aging & Frontal Executive System; Brain Health
(01:39:26) Tools: Brain Health & Boosting Executive Function, Books
(01:47:26) Alzheimer’s Disease, Genetics, Pharmacology
(01:51:48) Parkinson’s Disease, L-Dopa; Coping with Alzheimer’s; Nicotine
(01:58:37) Estrogen & Dopamine, Cognition; Tool: Physical Exercise
(02:04:43) Tool: Mindfulness Meditation & Executive Function
(02:10:31) Brain Networks; Modularity
(02:17:08) Modularity, Brain Indices
(02:22:53) Psilocybin; Transcranial Magnetic Stimulation
(02:30:16) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter