The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

Essentials: How to Control Your Sense of Pain & Pleasure

June 19, 2025 0:37:13 7.05 MB ( -7.06 MB less) Downloads: 0

In this Huberman Lab Essentials episode, I explore the sensations of pain and pleasure, explaining how they are sensed in the body and interpreted by the brain as well as methods to control their intensity.

I discuss both the hardwired mechanisms and subjective factors that shape an individual’s perception of pain and pleasure. I also explain why pain thresholds vary from person to person and discuss various treatments for pain management such as acupuncture and supplements. Finally, I explain the role of key neurochemicals like dopamine and serotonin in mediating our experience of pain and pleasure.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

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Timestamps

00:00:00 Pain & Pleasure

00:00:39 Skin, Appetitive vs Aversive Behaviors

00:02:10 Skin, Neurons & Brain

00:04:46 Brain Interpretation, Homunculus, Two-Point Discrimination Test

00:07:43 Pain & Pleasure, Subjective Interpretation

00:09:53 Sponsor: AG1

00:11:30 Tool: Pain & Expectation

00:13:08 Pain Threshold

00:14:46 Heat & Cold, Tool: Moving into Cold or Hot Environments

00:16:37 Subjective Pain, Psychosomatic, Fibromyalgia, Whole Body Pain, Acetyl-L-carnitine

00:20:54 Acupuncture, Electroacupuncture, Pain Management

00:23:44 Sponsors: LMNT & Eight Sleep

00:26:36 Red Heads & Pain Threshold, Endorphins

00:28:32 Improving Pain Threshold, Dopamine

00:30:00 Pleasure, Dopamine, Serotonin; Depression, Anti-depressants

00:34:12 Pleasure & Pain Balance, Dopamine, Addiction

00:36:08 Recap & Key Takeaways

Disclaimer & Disclosures

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