The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

December 25, 2025 0:42:10 7.27 MB ( -7.28 MB less) Downloads: 0

In this Huberman Lab Essentials episode, my guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health.

We explain how to improve hormone levels across the lifespan in both men and women using behavioral, nutritional and exercise-based tools. We also discuss common clinical topics, including hormone testing, PCOS, hair loss, testosterone replacement therapy (TRT) and peptides, focusing on potential benefits, tradeoffs and risks.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

AG1: https://drinkag1.com/huberman

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Function: https://functionhealth.com/huberman

Timestamps

(00:00:00) Kyle Gillett

(00:00:36) Hormone Health; Women vs Men, Tool: Hormone Testing

(00:02:35) Tool: Big 6 Lifestyle Pillars to Optimize Hormone Health

(00:04:32) Sponsor: AG1

(00:06:17) Diet, Individualization; Bloodwork & Frequency

(00:07:20) Exercise, Zone 2 Cardio; Caloric Restriction

(00:08:36) Intermittent Fasting, Growth Hormone, IGF-1

(00:11:05) Hormones & Sleep, Growth Hormone, Menopause, Andropause, TRT

(00:13:28) Testosterone & Women, SHGB

(00:15:19) Sponsor: Maui Nui

(00:16:34) Dihydrotestosterone (DHT), Androgens; Turmeric & Black Pepper; Hair Loss

(00:19:47) Polycystic Ovarian Syndrome (PCOS), Symptoms, Metformin, Inositol

(00:23:13) Cannabis, Alcohol, Testosterone

(00:24:48) Males & Testosterone, TRT, Prostate Cancer

(00:26:04) Prolactin, Dopamine "Wave Pool", Tool: Casein & Gluten

(00:27:23) Sponsor: Function

(00:29:03) Social Relationships & Hormones, Tool: Planning for Crisis

(00:31:02) Peptides, Growth Hormone & Risk; BPC 157, Sourcing & LPS

(00:36:42) Melanotan, Uses & Risks

(00:38:45) Spiritual Health, Interdisciplinary Health Integration

(00:41:23) Caffeine & Hormones, Sleep; Acknowledgements

Disclaimer & Disclosures

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