The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.
Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson
Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy.
Read the show notes at hubermanlab.com.
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Timestamps
(00:00:00) Alex Marson
(00:02:21) Diseases & Current Biological Landscape; AI & Computational Tools
(00:05:56) Immune System, Innate vs Adaptive Immune System
(00:10:55) Thymus, T Cell Selection; B Cells & Antibodies
(00:13:23) Sponsors: BetterHelp & Helix Sleep
(00:16:11) Immune System Health, Sleep, Diet; Genes
(00:20:56) Childhood Exposure & Allergy Prevention; Autoimmune Reactions
(00:25:27) Whole Body Immune Response, Cytokines & Fever; Antibiotics
(00:30:51) Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight
(00:38:27) BRAC Mutations, Mutagens, Pesticides
(00:42:33) Sponsor: AG1
(00:43:57) X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye
(00:49:34) Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy
(00:59:04) CRISPR, Immunotherapies
(01:02:52) Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet
(01:08:27) CRISPR Discovery & Mechanism
(01:17:06) CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution
(01:20:57) Sponsor: LMNT
(01:22:17) CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention
(01:33:47) Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines
(01:39:57) COVID Pandemic & Trust in Science, mRNA Vaccine
(01:47:51) Sponsor: Function
(01:49:39) Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets
(01:55:45) CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity
(02:05:42) Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience
(02:10:44) Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function
(02:17:55) Banking T Cells or iPSCs?, Future of Cell Programming
(02:24:41) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
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