The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.
How Mitochondria Control Your Metabolism | Dr. Jared Rutter
Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases.
Show notes: https://go.hubermanlab.com/297-jared-rutter
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Timestamps
(00:00:00) Jared Rutter
(00:02:29) Metabolism, Cells; Aging
(00:08:36) Mitochondria, Origin & Cell Complexity
(00:13:07) Sponsors: Joovv & BetterHelp
(00:15:16) Mitochondria Genome, Inheritance
(00:18:18) Mitochondria & Spatial Distribution; Cell-Specific Metabolism
(00:25:59) Nutrient Energy, Hormones, Fat Cells
(00:31:13) Glucose, ATP Conversion, Pyruvate
(00:36:41) Cell Choice: Energy or Growth, Cancer; Virus
(00:46:02) Sponsors: AG1 & Eight Sleep
(00:48:36) Microbiome, Role of Humans
(00:51:44) Molecule Discovery Process, MPC1, MPC2
(00:59:42) Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart
(01:07:03) Cell Resource Allocation, MPC, Heart Failure; Disease
(01:11:46) Sponsor: Function
(01:13:24) Cell Size vs Fuel Balance, Cell Identity & Disease
(01:20:43) MPC Discovery, Genetics, Model Systems
(01:24:29) Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy
(01:31:32) Cancer, Mutations, Metabolism Changes & Warburg Effect
(01:36:18) Cancer Challenges & Therapies
(01:43:00) Therapy Combinations, Unique Cancer Mutations & Metabolism
(01:48:31) Technology to Visualize Metabolism; Disease, Metabolism & Scents
(01:56:34) Excess Energy & Mitochondria, Reactive Oxygen Species
(02:01:12) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
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