The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.
Essentials: Genes & the Inheritance of Memories Across Generations | Dr. Oded Rechavi
In this Huberman Lab Essentials episode, my guest is Dr. Oded Rechavi, a professor at Tel Aviv University who studies genetics, epigenetics and the inheritance of acquired traits. We discuss how DNA, RNA and epigenetic mechanisms determine what information can pass between generations, and why acquired traits are generally not thought to be inherited. We also explain research in C. elegans showing how small RNAs can transmit antiviral resistance and influence behavior across generations, what these findings might mean for mammals and humans, and potential future applications for reproductive health and diagnostics.
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Timestamps
(00:00:00) Oded Rechavi
(00:00:24) DNA, Genome, RNA & Proteins
(00:03:43) Somatic vs. Germ Cells; Inheritance
(00:06:05) Sponsor: Eight Sleep
(00:07:23) Lamarck vs. Darwin, Inheritance of Acquired Traits
(00:09:45) Weismann Barrier, Epigenetic Reprogramming
(00:13:05) RNA & Transgenerational Inheritance
(00:13:54) Model Organisms, C. elegans
(00:16:59) Inheritance of Acquired Traits in C. elegans
(00:17:14) Sponsor: AG1
(00:18:40) RNA Interference, Small RNAs & Gene Silencing
(00:22:46) Viral Resistance Across Generations
(00:24:53) Small RNAs, Mammals & Inherited Effects
(00:26:00) Brain Activity, Memory & Heritable Information
(00:28:46) Neuronal Small RNAs & Behavior Across Generations
(00:29:59) Germ Cells, Development & Heritable RNA
(00:31:29) Sponsor: LMNT
(00:33:11) Future Applications, Exercise, IVF & RNA Diagnostics
(00:35:16) Acknowledgements
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