Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.
#524: 38 things Python developers should learn in 2025
October 20, 2025
01:09:15
12.8 MB ( 53.97 MB less)
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Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In this episode, we count down 38 things to learn this year: free-threaded CPython, uv for packaging, Docker and Compose, Kubernetes with Tilt, DuckDB and Arrow, PyScript at the edge, plus MCP for sane AI workflows. Expect practical wins and migration paths. No buzzword bingo, just what pays off in real apps. Join me along with Peter Wang and Calvin Hendrix-Parker for a fun, fast-moving conversation.
Episode sponsors
Seer: AI Debugging, Code TALKPYTHON
Agntcy
Talk Python Courses
Peter on BSky: @wang.social
Free-Threaded Wheels: hugovk.github.io
Tilt: tilt.dev
The Five Demons of Python Packaging That Fuel Our ...: youtube.com
Talos Linux: talos.dev
Docker: Accelerated Container Application Development: docker.com
Scaf - Six Feet Up: sixfeetup.com
BeeWare: beeware.org
PyScript: pyscript.net
Cursor: The best way to code with AI: cursor.com
Cline - AI Coding, Open Source and Uncompromised: cline.bot
Watch this episode on YouTube: youtube.com
Episode #524 deep-dive: talkpython.fm/524
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
Episode sponsors
Seer: AI Debugging, Code TALKPYTHON
Agntcy
Talk Python Courses
Links from the show
Calvin Hendryx-Parker: github.com/calvinhpPeter on BSky: @wang.social
Free-Threaded Wheels: hugovk.github.io
Tilt: tilt.dev
The Five Demons of Python Packaging That Fuel Our ...: youtube.com
Talos Linux: talos.dev
Docker: Accelerated Container Application Development: docker.com
Scaf - Six Feet Up: sixfeetup.com
BeeWare: beeware.org
PyScript: pyscript.net
Cursor: The best way to code with AI: cursor.com
Cline - AI Coding, Open Source and Uncompromised: cline.bot
Watch this episode on YouTube: youtube.com
Episode #524 deep-dive: talkpython.fm/524
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy